Fig. 7: Morphology of rod-cre PKM2-KO retina and assessment of rod outer segment integrity.
From: Pyruvate kinase M2 regulates photoreceptor structure, function, and viability
Morphologic examination of three independent mouse retinas from 5-month-old wild-type a–c and rod-cre PKM2-KO mice d–f. GCL, ganglion cell layer; INL, inner nuclear layer; IPL, inner plexiform layer; ONL, outer nuclear layer; OPL, outer plexiform layer; RPE, retinal pigment epithelium; ROS, rod outer segments. Scale bar = 50 μm. Quantification of morphological changes h. Plots of total retinal thickness in the inferior and superior regions of the retinas of wild-type, and rod-cre PKM2-KO mice are shown. Values are mean ± SEM (n = 3). ONH, optic nerve head
