Table 2 DNA repair genes downregulated in common in four different microarray datasets of senescence
From: Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence
Gene symbol | Protein name | WI38 ETO | IMR90 RAS | HUVEC RS | HMEC MEK |
|---|---|---|---|---|---|
BARD1 | BRCA1-associated RING domain protein 1 | 6 | 3 | 4.4 | 4.7 |
BLM | Bloom syndrome protein | 4.8 | 3.9 | 9.4 | 5.5 |
BRCA1 | Breast cancer type 1 susceptibility protein | 3.8 | 2.2 | 5.6 | 5.5 |
CDC45 | Cell division control protein 45 homolog | 9.5 | 2.6 | 10 | 5.9 |
CDC7 | Cell division cycle 7-related protein kinase | 6.5 | 2 | 2.7 | 5.5 |
CDCA5 | Sororin | 9.8 | 3.2 | 8.5 | 5.9 |
CDK1 | Cyclin-dependent kinase 1 | 12.1 | 2.8 | 11 | 7.7 |
CHAF1A | Chromatin assembly factor 1 subunit A | 5.6 | 2.1 | 4.6 | 5.0 |
CHAF1B | Chromatin assembly factor 1 subunit B | 6.2 | 2 | 3.7 | 4.3 |
DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2 | 3 | 2.1 | 4.4 | 2.8 |
EXO1 | Exonuclease 1 | 11.3 | 4.2 | 9 | 7.0 |
FANCB | Fanconi anemia group B protein | 3.2 | 2.3 | 4.7 | 3.4 |
FANCD2 | Fanconi anemia group D2 protein | 4.8 | 5.1 | 8 | 5.6 |
FANCG | Fanconi anemia group G protein | 5.4 | 2.2 | 3 | 2.6 |
FANCI | Fanconi anemia group I protein | 6.3 | 3.9 | 4.7 | 4.1 |
FEN1 | Flap endonuclease 1 | 6.7 | 2.1 | 6.9 | 3.8 |
FOXM1 | Forkhead box protein M1 | 18.4 | 5.6 | 7.5 | 4.5 |
HMGB1 | High mobility group protein B1 | 2.6 | 2.1 | 2.7 | 2.4 |
HMGB2 | High mobility group protein B2 | 3.4 | 9.1 | 5.1 | 4.5 |
KIAA0101 | PCNA clamp associated factor | 11.3 | 4.2 | 4.2 | 6.4 |
NEIL3 | Endonuclease 8-like 3 | 4.9 | 7.5 | 12.6 | 9.1 |
NUDT1 | 7,8-dihydro-8-oxoguanine triphosphatase | 5.8 | 2.3 | 2.1 | 2.4 |
PARPBP | PCNA-interacting partner | 7.6 | 2.1 | 3.4 | 6.8 |
PIF1 | ATP-dependent DNA helicase PIF1 | 2.0 | 2.1 | 8.1 | 5.4 |
POLA1 | DNA polymerase alpha catalytic subunit | 6.5 | 4 | 4 | 2.3 |
POLE2 | DNA polymerase epsilon subunit 2 | 9.6 | 6.3 | 11.5 | 8.5 |
POLQ | DNA polymerase theta | 10.1 | 3.4 | 11.2 | 7.5 |
PTTG1 | Securin | 11.1 | 4.4 | 5.5 | 4.3 |
RAD51 | DNA repair protein RAD51 homolog 1 | 6.3 | 2.7 | 10.7 | 4.7 |
RAD51AP1 | RAD51-associated protein 1 | 6.5 | 5.9 | 9.7 | 10.0 |
RAD54B | DNA repair and recombination protein RAD54B | 3.6 | 2.1 | 2.1 | 2.7 |
RAD54L | DNA repair and recombination protein RAD54-like | 7.2 | 2.1 | 9.3 | 3.8 |
RFC3 | Replication factor C subunit 3 | 4.9 | 4.8 | 6.1 | 9.0 |
RFC4 | Replication factor C subunit 4 | 3.7 | 3.2 | 4.1 | 4.3 |
RFC5 | Replication factor C subunit 5 | 5.8 | 2.5 | 4.5 | 4.1 |
RNASEH2A | Ribonuclease H2 subunit A | 9.1 | 3.4 | 2.7 | 2.7 |
TRIP13 | Pachytene checkpoint protein 2 homolog | 19.3 | 2.3 | 11.3 | 6.6 |
UBE2T | Ubiquitin-conjugating enzyme E2 T | 6.4 | 2.4 | 5.7 | 4.0 |
USP1 | Ubiquitin carboxyl-terminal hydrolase 1 | 7.3 | 5.3 | 3.7 | 2.5 |
