Fig. 8: Effect of PXA on mitochondrial matrix morphology.
From: The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane
a Confocal images of MEF cells (WT and DRP1-KO) at 30 min after treatment with either 0.1% v/v DMSO (vehicle control), 10 µM CCCP (positive control for fragmentation) or 10 µM PXA. HSP60 (green) was stained as a marker for the mitochondrial matrix, and TOMM20 (red) was stained as a marker for the outer mitochondrial membrane (OMM). Scale bars are equivalent to 10 µm. b Quantification of mitochondrial morphology by classification of 200 individual cells in each of three independent experiments; error bars = SD. c Transmission electron microscopy images of MEF cells (WT or OMA1-KO) after treatment with either 10 µM PXA or with 0.1% v/v DMSO (vehicle control) for 30 min. Scale bars are equivalent to 0.5 µm
