Fig. 2: Downregulation of PEAK1 inhibits CRC cell invasion, migration and proliferation. | Cell Death & Disease

Fig. 2: Downregulation of PEAK1 inhibits CRC cell invasion, migration and proliferation.

From: PEAK1, acting as a tumor promoter in colorectal cancer, is regulated by the EGFR/KRas signaling axis and miR-181d

Fig. 2

a Transwell assays were used to estimate the effects of PEAK1 downregulation on CRC cell invasion abilities. b, c Real-time migration and real-time proliferation of CRC cells transfected with NC or siPEAK1. The delta cell index indicates electrical impedance measurements. All the above experiments were carried out in triplicate. d The tumor growth curve. HCT 116 cells were transfected with pLenti-shRNA or pLenti-vector and subcutaneously injected into nude mice. Statistical significance was determined by Student’s paired t-test. (n = 12 per group). e Photographs of the tumors at day 21 after inoculation with HCT 116 cells transfected with pLenti-shRNA or pLenti-vector (up). Average tumor weight after tumor excision (down). (Data are represented as the mean ± s.d. *P < 0.05, **P < 0.01)

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