Fig. 8: The proposed role of cinacalcet in diabetic nephropathy and the interplay between cinacalcet and kidney, especially glomerular endothelial cells (GECs) and podocytes, in type 2 diabetes. | Cell Death & Disease

Fig. 8: The proposed role of cinacalcet in diabetic nephropathy and the interplay between cinacalcet and kidney, especially glomerular endothelial cells (GECs) and podocytes, in type 2 diabetes.

From: Cinacalcet-mediated activation of the CaMKKβ-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and autophagy

Fig. 8

AMPK AMP-activated protein kinase, CaMKKβ Ca2+/calmodulin-dependent protein kinase kinaseβ, CaSR calcium-sensing receptor, LKB1 liver kinase B1, [Ca2+]i intracellular calcium, PGC-1α peroxisome proliferator-activated receptor γ coactivator 1-α

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