Figure 1: High microRNA-146a (miR-146a) level in non-classical monocytes does not limit the LPS response. | Cell Death & Disease

Figure 1: High microRNA-146a (miR-146a) level in non-classical monocytes does not limit the LPS response.

From: The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence

Figure 1: High microRNA-146a (miR-146a) level in non-classical monocytes does not limit the LPS response.

a Gating of enriched monocytes to generate the three monocyte subsets based on CD14 and CD16 expression. b Basal miR-146a expression in the three monocyte subsets. c TNF-α mRNA up-regulation in the three monocyte subsets, as an acute response to 2 h LPS stimulation. TNF-α mRNA level expressed as a fold change with respect to basal level before LPS stimulation. The data represent the means ± SD; n ≥ 3; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. CL: classical, ITM: intermediate, NC: non-classical

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