Fig. 9: Putative model of the mechanisms underlying increased mitochondrial fission in PE.
From: Ceramide-induced BOK promotes mitochondrial fission in preeclampsia
Putative model of the mechanisms underlying increased mitochondrial fission in PE. Elevated ceramide in mitochondria from PE pregnancies activates DRP1 and increases its recruitment to MFF at the OMM. p-DRP1 oligomerizes and completes the process of mitochondrial fission. Ceramide triggers the recruitment of BOK to the OMM, which; in turn, contributes to both augmented p-DRP1 expression and increases MAM tethering by inducing MFN2 expression. Mitochondrial fragments are degraded by means of PINK1/Parkin dependent mitophagy
