Fig. 6: Schematic overview of the PI3K/Akt/BRCA1-A complex pathway in the Sei-1-transformed NIH-3T3 cell model | Cell Death & Disease

Fig. 6: Schematic overview of the PI3K/Akt/BRCA1-A complex pathway in the Sei-1-transformed NIH-3T3 cell model

From: Sei-1 promotes double minute chromosomes formation through activation of the PI3K/Akt/BRCA1-Abraxas pathway and induces double-strand breaks in NIH-3T3 fibroblasts

Fig. 6

. Sei-1 activates the PI3K/Akt pathway independent of PTEN and inhibits the expression of the BRCA1-A complex to result in DSBs, leading to the formation of DMs in vivo. Sei-1 can also target the promoter and regulate the expression of BRCA1

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