Fig. 5: The inhibitory effect of dioscin on osteosarcoma stem-cell-like properties and tumor growth depends on Wnt/β-catenin pathway. | Cell Death & Disease

Fig. 5: The inhibitory effect of dioscin on osteosarcoma stem-cell-like properties and tumor growth depends on Wnt/β-catenin pathway.

From: Dioscin inhibits stem-cell-like properties and tumor growth of osteosarcoma through Akt/GSK3/β-catenin signaling pathway

Fig. 5

a The efficiency of β-catenin-shRNA was examined by western blot. b−d Dioscin has a minimal effect on proliferation (b), colony formation (c) and sarcospheres formation (d) of osteosarcoma cells with β-catenin knockdown. e The efficiency of β-catenin-overexpression was examined by western blot. f−h The impairment of dioscin on proliferation (f), colony formation (g) and sarcospheres formation (h) was partly rescued by overexpressing β-catenin in osteosarcoma cells. Data represent the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001 by two-tailed Student’s t test, SPSS 20.0

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