Fig. 4: Galunisertib reduces clonogenicity and liver spheroid formation ability of HCC invasive cells. | Cell Death & Disease

Fig. 4: Galunisertib reduces clonogenicity and liver spheroid formation ability of HCC invasive cells.

From: Galunisertib suppresses the staminal phenotype in hepatocellular carcinoma by modulating CD44 expression

Fig. 4

a Colony formation assay. After galunisertib treatment, HLE (left panel) and HLF (right panel) cells were serially diluted into 500, 200, and 100 cells and cultured for 12 days. Data represent quantification of the number of colonies per well. b Ability of growing in spheroids in the absence of attachment. The % of wells with spheroids during first, second, and third cell generation is shown. c Variation on the area of liver spheroids during first, second, and third cell generation is shown. Mean ± SEM (N at least 3). *P < 0.05; **P < 0.001; ***P < 0.0001

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