Fig. 6: Absence of Rap1 downregulates NF-κB activity in MSCs. | Cell Death & Disease

Fig. 6: Absence of Rap1 downregulates NF-κB activity in MSCs.

From: Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation

Fig. 6: Absence of Rap1 downregulates NF-κB activity in MSCs.

a Western blotting showed the activity of NF-κB pathway in active status with/without NF-κB inhibitor QNZ treatment. b Cytokine profiling showed that Rap1 deficiency downregulated NF-κB-related cytokine secretion in MSCs (n = 3 for each group). *p < 0.05; **p < 0.01; ***p < 0.001; N: non-significance.

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