Table 2 Univariate and multivariate analyses of factors associated with survival and recurrence
From: PFKFB3 blockade inhibits hepatocellular carcinoma growth by impairing DNA repair through AKT
Clinicopathological Factors | Ā | Overall survival | Ā | Disease-free survival | ||||
|---|---|---|---|---|---|---|---|---|
| Ā | Univariate P | Multivariate | Univariate P | Multivariate | ||||
| Ā | Hazard ratio | 95% CI | P | Hazard ratio | 95% CI | P | ||
Age: ā¤50 vs. >50 | 0.915 | Ā | Ā | NA | 0.254 | Ā | Ā | NA |
Gender: female vs. male | 0.387 | Ā | Ā | NA | 0.198 | Ā | Ā | NA |
Cirrhosis: no vs. yes | 0.429 | Ā | Ā | NA | 0.429 | Ā | Ā | NA |
HBsAg: negative vs. positive | 0.395 | Ā | Ā | NA | 0.501 | Ā | Ā | NA |
AFP: ā¤20 vs. >20āng/ml | 0.105 | Ā | Ā | NA | 0.065 | Ā | Ā | NA |
Size: ā¤ā5 vs. >5ācm | 0.000 | 2.165 | 1.497 to 3.130 | 0.000 | 0.000 | 1.737 | 1.253ā2.410 | 0.001 |
Number: single vs. multiple | 0.009 | Ā | Ā | NS | 0.000 | Ā | Ā | NS |
Thrombus: no vs. yes | 0.000 | Ā | Ā | NS | 0.000 | Ā | Ā | NS |
TNM: I vs. II vs. III | 0.000 | 1.817 | 1.118 to 2.952 | 0.016 | 0.000 | 1.623 | 1.052ā2.502 | 0.028 |
Encapsulation: yes vs. no | 0.235 | Ā | Ā | NS | 0.085 | Ā | Ā | NS |
Grade: I-II vs. III-IV | 0.012 | 1.432 | 1.001 to 2.049 | 0.049 | 0.004 | 1.513 | 1.098ā2.085 | 0.011 |
Intratumor PFKFB3 | 0.026 | 1.430 | 1.204 to 1.997 | 0.036 | 0.005 | 1.426 | 1.057ā1.923 | 0.020 |
