Fig. 7: Extracellular lactose regulates the nuclear localization of Gal-1. | Cell Death & Disease

Fig. 7: Extracellular lactose regulates the nuclear localization of Gal-1.

From: Nuclear galectin-1-FOXP3 interaction dampens the tumor-suppressive properties of FOXP3 in breast cancer

Fig. 7

a Confocal microscopy for the detection of Gal-1 expression in T47D cells embedded in 3D Matrigel-containing vehicle, soluble lactose, or conditional medium (CM) + lactose. Nuclear staining with DAPI is shown. Scale bar = 10 μm. b Quantification of nuclear:total Gal-1 ratio in T47D cells shown in a. c Confocal microscopy for the detection of Gal-1 expression in MCF-7 cells embedded in 3D Matrigel-containing vehicle, soluble lactose or conditional medium (CM) + lactose. Nuclear staining with DAPI is shown. Scale bar = 10 μm. d Quantification of nuclear:total Gal-1 ratio in MCF-7 cells shown in c. b,d The data are shown as the mean ± s.e.m. ***P < 0.001. b,d ANOVA with Dunnett’s t-test

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