Fig. 1: Microarray analysis of gastric tumors reveals reduced PCAF, ADA3, and PACS1 mRNA expression.
From: Down-regulation of a pro-apoptotic pathway regulated by PCAF/ADA3 in early stage gastric cancer
A cohort of gastric cancer samples and associated premalignant lesions were profiled using Affymetrix U133+2 arrays; data is presented as Normalized Intensity Value (NIV). Tumor tissue was classified histologically into Diffuse (D) or Intestinal (I) subtypes and compared to non-malignant (NM) gastric tissue which was further subdivided into Chronic Gastritis (CG) or Intestinal Metaplasia (IM). a shows relative PCAF mRNA expression during the progression to GC; b samples were further stratified based on tumor stage and subtype, c relative PCAF mRNA expression was then determined for paired CG and intestinal GC and d IM and paired intestinal GC samples. The relationship between e ADA3 and f PACS1 expression during progression was also determined. The boxes on the whisker plots show the mean and 25th percentile values throughout. Error bars are SEM, statistical analysis performed: 2-way ANOVA and Bonferroni test or t-test, *P < 0.05 and **P < 0.01
