Fig. 1: Dynamic changes in levels of bone marrow (BM) progenitor cells and decrease of CACs in diabetic mice. | Cell Death & Disease

Fig. 1: Dynamic changes in levels of bone marrow (BM) progenitor cells and decrease of CACs in diabetic mice.

From: Reduction of Endoplasmic Reticulum Stress Improves Angiogenic Progenitor Cell function in a Mouse Model of Type 1 Diabetes

Fig. 1

Mononuclear cells from peripheral blood or the BM of diabetic (DM) mice at 1, 3, 6, and 9 months after the onset of diabetes and their respective non-diabetic (NDM) controls were separated by Ficoll gradient centrifugation. a Numbers of CACs (Flk-1+/Sca-1+/CD34+) in the peripheral blood. b Numbers of BM-HSCs (Lin−/c-Kit+/Sca-1+/CD34+). c Numbers of BM-CACs (Flk-1+/Sca-1+/CD34+; n = 3–6 mice per group). All data are presented as mean ± SD. *P < 0.05, ***P < 0.001 vs. age-matched NDM control mice (two-way ANOVA with bonferroni post hoc test)

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