Fig. 2: Assessment of LDH release of human islets pre-treated with or without Fer-1 or DFO in the presence of erastin.
From: Ferroptosis-inducing agents compromise in vitro human islet viability and function
a–c Human islets exhibit significantly reduced islet cell death when pre-treated for 24 h with 1, 5, or 10 μM Fer-1 and subsequently challenged with erastin for an additional 24 h. **p < 0.01, ***p < 0.001, ****p < 0.0001 (one-way ANOVA). d 1 μM Fer-1 and 100 μM DFO exhibited reduced LDH release in the presence of 50 μM Fer-1 erastin relative to erastin-alone-treated islets. **p < 0.01, ***p < 0.001, ****p < 0.0001 (one-way ANOVA). Data represented as mean ± SEM, Triplicate samples from at least three human pancreata
