Fig. 6: MEK2 mediates USP21 oncogenic phenotypes.
From: The deubiquitinase USP21 stabilizes MEK2 to promote tumor growth
a Immunoblotting of USP21, MEK2, p-Erk1/2, Erk1/2, p-Erk1/2 and β-actin in HL7702 and MHCC97L cells transfected with retrovirus carrying empty vector or USP21-FLAG. b Immunoblotting of USP21, MEK2, p-ERK1/2, ERK1/2 and β-actin in USP21 shRNA-transduced FHCC98 and HepG2 cells with or without ectopic expression of MEK2. c Growth curves of cells from b. d Quantification of soft agar colony of cells from b. e Cell cycle analyses of cells from b. Unless noted, p-values are based on Student’s two-tailed t-test: **p < 0.01
