Fig. 1: IDH2 deficiency aggravates renal histological and functional impairments after cisplatin administration. | Cell Death & Disease

Fig. 1: IDH2 deficiency aggravates renal histological and functional impairments after cisplatin administration.

From: Mitochondrial NADP+-dependent isocitrate dehydrogenase deficiency increases cisplatin-induced oxidative damage in the kidney tubule cells

Fig. 1

Idh2‒/‒ mice and wild-type (Idh2+/+) littermates were intraperitoneally injected with either cisplatin (C, 20 mg/kg B.W.) or 0.9% saline (vehicle, V) once. Some mice were treated with Mito-T (M, 0.7 mg/kg B.W.) daily, beginning 7 days before cisplatin injection and continuing until experiments were completed. Three days after cisplatin injection, renal functional and histological impairment were determined. a Kidney sections were stained with periodic acid Schiff reagent. Asterisks indicate damaged tubules. b Tubular damage score was obtained as described in the “Materials and methods” section. c, d Concentrations of blood urea nitrogen (BUN) and plasma creatinine (PCr) were determined 3 days after cisplatin injection. Results are expressed as means ± SE (n = 5). Scale bars: a 100 µm. *p < 0.05 vs. respective V; #p < 0.05 vs. respective C; §p < 0.05 vs. V in Idh2+/+; †p < 0.05 vs. C in Idh2+/+

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