Fig. 6: Age-dependent decline of motor activity, coordination, and cognitive tasks of SMPD3-deficient mice. | Cell Death & Disease

Fig. 6: Age-dependent decline of motor activity, coordination, and cognitive tasks of SMPD3-deficient mice.

From: SMPD3 deficiency perturbs neuronal proteostasis and causes progressive cognitive impairment

Fig. 6: Age-dependent decline of motor activity, coordination, and cognitive tasks of SMPD3-deficient mice.

Assessment of motor activity and coordination by a Rota-rod task, b beam walk task, and c open field test, working memory by d T-maze, reference memory by e RAWM of Cntr and smpd3-/- mice, age 12 mo, f thigmotaxis in open field task and anxiety response by g, h elevated plus-maze. N = 8, mean ± SD. p values of ≤ 0.05 *, ≤ 0.01 **, ≤ 0.001 *** were considered significant

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