Fig. 7: Exogenous expression of PLAC8 rescued the KLF4-induced inhibition of H1299 cell growth.
From: The novel KLF4/PLAC8 signaling pathway regulates lung cancer growth
a PLAC8 and KLF4 expression level in H1299 cell lines transfected with a KLF4-overexpressing vector or a PLAC8-overexpressing vector. GAPDH served as the endogenous control. b Exogenous PLAC8 expression partially reverted the growth arrest in H1299 cells, whereas KLF4 induced complete growth arrest. c Exogenous PLAC8 expression impeded KLF4-induced apoptosis. d KLF4-related cell arrest in the S phase was reverted by PLAC8 overexpression. Data are presented as the mean ± SD derived from three separate experiments. *P < 0.05 and **P < 0.01
