Fig. 2: KA-induced ER stress and autophagy.
From: P2RX7-MAPK1/2-SP1 axis inhibits MTOR independent HSPB1-mediated astroglial autophagy
a Representative western blot of ER stress- and autophagy-related molecules in the whole hippocampus (Left panels) and isolated astrocytes (Right panels). P2rx7 deletion induces ER stress and autophagy following KA injection. Cont control animals, KA/3D 3 days post KA injected in animals, KA/7D 7 days post KA injected in animals. b–c Quantifications of ER stress-related molecules in the whole hippocampus (b) and isolated astrocytes (c) following KA injection. Open circles indicate each individual value. Horizontal bars indicate mean value. Error bars indicate SEM (*,#p < 0.05 vs. control and WT mice, respectively; n = 7, respectively)
