Fig. 5: DDX39 activates Wnt/β-catenin pathway. | Cell Death & Disease

Fig. 5: DDX39 activates Wnt/β-catenin pathway.

From: DDX39 promotes hepatocellular carcinoma growth and metastasis through activating Wnt/β-catenin pathway

Fig. 5

a GSEA analysis of the correlation between DDX39 levels and Wnt3A target gene signatures using TCGA data. b TOP/FOP luciferase activity assay revealed DDX39 overexpression activated Wnt/β-catenin pathway. DDX39 knockdown inhibited Wnt/β-catenin pathway. c Western blot analysis of β-catenin levels in nucleus of HCC cells with DDX39 overexpression or knockdown, EF-1α was used as the loading control. d qRT-PCR analyzed the expression of Wnt/β-catenin target genes like MYC, CD44, RUNX2, SNAIL1, and CCND1 in HCC cells with DDX39 overexpression or knockdown. Data are shown as means ± SD. *p < 0.05

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