Fig. 6: DDX39 promotes HCC progression through activating Wnt/β-catenin pathway. | Cell Death & Disease

Fig. 6: DDX39 promotes HCC progression through activating Wnt/β-catenin pathway.

From: DDX39 promotes hepatocellular carcinoma growth and metastasis through activating Wnt/β-catenin pathway

Fig. 6

a Western blot assay of TCF4 and LEF1 expression in HCC cells overexpressing DDX39 transfected with siRNAs for TCF4 or LEF1. b qRT-PCR analyzed the expression of Wnt/β-catenin target genes like MYC, CD44, RUNX2, SNAIL1, and CCND1 in HCC cells overexpressing DDX39 transfected with siRNAs for TCF4 or LEF1. c Transwell assay of the effect of TCF4 or LEF1 knockdown in HCC cells overexpressing DDX39 on cell invasion. d 3D spheroid invasion assay of the effect of TCF4 or LEF1 knockdown in HCC cells overexpressing DDX39 on cell invasion. Data are shown as means ± SD. *p < 0.05

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