Fig. 6: Effect of GX1 on co-HUVEC apoptosis and migration after TGM2 downregulation with siRNAs. | Cell Death & Disease

Fig. 6: Effect of GX1 on co-HUVEC apoptosis and migration after TGM2 downregulation with siRNAs.

From: Novel peptide GX1 inhibits angiogenesis by specifically binding to transglutaminase-2 in the tumorous endothelial cells of gastric cancer

Fig. 6: Effect of GX1 on co-HUVEC apoptosis and migration after TGM2 downregulation with siRNAs.

a (panels a, b, c) Western blotting analysis of GX1-receptor and TGM2-antibody in TGM2 knockdown co-HUVECs. *P < 0.05; **P < 0.01; n = 3. b Flow cytometry analysis of TGM2 knockdown apoptotic co-HUVECs treated with or without GX1 (0.1 mg/ml, 48 h). Transwell (c) and wound healing (d) assays to measure the alterations of GX1-mediated inhibition of co-HUVECs migration after TGM2 downregulation. *P < 0.05; ***P < 0.001; n = 4

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