Table 2 The top 10 of the results of mRNAs with an up or downregulation in expression in the hepatic damage models compared with control

Gene symbol	Seq name	Fold change	P value	Reg.	RNA length (b)	Model (raw)	Control (raw)	Model (normalized)	Control (normalized)
S100a9	NM_009114	93.28	<0.001	Up	488	1697.10	21.85	11.02	4.48
Cd177	NM_026862	83.11	<0.001	Up	2733	911.45	8.10	9.43	3.05
Csta	NM_001033239	82.98	<0.001	Up	2731	1008.21	5.58	9.07	2.69
Lcn2	NM_008491	74.53	<0.001	Up	853	10,2947.34	1757.61	16.61	10.39
S100a8	NM_013650	49.25	<0.001	Up	392	41,037.86	775.43	14.95	9.33
Ctsg	NM_007800	41.47	<0.001	Up	1004	3485.29	52.37	11.00	5.62
BC100530	NM_001082546	39.04	<0.001	Up	453	6273.79	87.57	11.70	6.41
Stfa1	NM_001082543	38.22	<0.001	Up	418	2755.89	27.06	10.04	4.79
Mzb1	NM_027222	38.02	<0.001	Up	928	10,548.88	221.29	12.90	7.66
S100g	NM_009789	33.85	<0.001	Up	480	1528.51	26.02	9.76	4.67
Elovl3	NM_007703	314.88	<0.001	Down	1879	16.64	4321.26	3.28	11.58
Ugt2b38	NM_133894	282.58	<0.001	Down	1894	7.64	2367.94	2.64	10.78
Hamp2	NM_183257	245.42	<0.001	Down	439	20.41	5409.34	3.94	11.88
Abhd16a	NM_178592	199.24	<0.001	Down	1945	47.44	5833.68	4.35	11.98
Cul1	NM_012042	167.74	<0.001	Down	3171	7.52	1526.85	2.82	10.21
Nr1d2	NM_011584	164.74	<0.001	Down	4640	314.41	22,652.56	6.52	13.89
Rtp3	NM_153100	158.51	<0.001	Down	2460	9.51	1343.63	2.74	10.05
Gbe1	NM_028803	133.96	<0.001	Down	2988	8.00	1267.99	2.91	9.97
Cyp8b1	NM_010012	130.48	<0.001	Down	1950	3977.65	182,298.87	9.86	16.89
Fbxw14	NM_015793	123.90	<0.001	Down	1497	120.10	7174.67	5.31	12.26

To identify differentially expressed mRNAs, we performed a fold change (FC) filtering between CCl₄ and control groups. The cutoff standard is the top 1% FC arranged from high to low. Seq name—mRNA name. Absolute fold change—absolute fold change between the two groups. Reg—regulation in the hepatic damage model compared to control; “Up” indicates upregulated mRNA in hepatic damage model compared with control; “Down” indicates downregulated one in hepatic damage model compared with control. Model-normal (raw)—raw intensities of each sample. Model-normal (normalized)—normalized intensities of each sample (log2-transformed). The list only shows the top 10 of the results of mRNAs with an up or downregulation in expression in the hepatic damage models vs. control

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