Fig. 2: MSCs downregulate the pro-inflammatory cytokine-producing CD8+ T cells partially through STC2 in vitro. | Cell Death & Disease

Fig. 2: MSCs downregulate the pro-inflammatory cytokine-producing CD8+ T cells partially through STC2 in vitro.

From: Stanniocalcin-2 contributes to mesenchymal stromal cells attenuating murine contact hypersensitivity mainly via reducing CD8+ Tc1 cells

Fig. 2: MSCs downregulate the pro-inflammatory cytokine-producing CD8+ T cells partially through STC2 in vitro.

CD3+CD8+ T cells were co-cultured with MSCs for 3 days, and flow cytometry was used to assess IFN-γ, TNF-α, and IL-2 production. a Representative plots of alteration in percentages of IFN-γ-producing CD8+ T cells, and bar chart showed the quantification (b). c Representative plots of alteration in percentages of TNF-α-producing CD8+ T cells, and bar chart showed the quantification (d). e Representative plots of alteration in percentages of IL-2-producing CD8+ T cells, and bar chart showed the quantification (f). Data are presented as mean ± SEM (n = 4). Statistically significant differences are indicated as follows: *p < 0.05 and **p < 0.01

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