Fig. 7: miR-3662 suppresses xenograft tumor growth in vivo. | Cell Death & Disease

Fig. 7: miR-3662 suppresses xenograft tumor growth in vivo.

From: MiR-3662 suppresses hepatocellular carcinoma growth through inhibition of HIF-1α-mediated Warburg effect

Fig. 7

a Upper panel: photographs of tumors derived from mice inoculated with SMMC7721-miR-3662-NC, SMMC7721-pre-miR-3662, and SMMC7721-miR-3662 inhibitor cells (n = 4 per group). Lower panel: growth curves for tumor volumes are shown (n = 4 per group). Tumor volume was calculated based on the following equation: Volume (mm3) = Length (mm) × Width2 (mm2) × 0.5. *P < 0.05 compared with the SMMC7721-miR-3662-NC group. b Tumor weight of the xenografts derived from mice inoculated with SMMC7721-miR-3662-NC, SMMC7721-pre-miR-3662, and SMMC7721-miR-3662 inhibitor cells (n = 4 per group). *P < 0.05 compared with the SMMC7721-miR-3662-NC group. c miR-3662 expression levels were analyzed by RT-qPCR in SMMC7721-miR-3662-NC, SMMC7721-pre-miR-3662, and SMMC7721-miR-3662 inhibitor xenografts. Three independent experiments were performed for each group. *P < 0.05, ***P < 0.001 compared with the SMMC7721-miR-3662-NC group. d Representative immunostaining images measuring HIF-1α and Ki-67 levels in tumors derived from mice inoculated with SMMC7721-miR-3662-NC, SMMC7721-pre-miR-3662, and SMMC7721-miR-3662 inhibitor cells. All data are presented as the means ± S.E.M

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