Fig. 2: No significant induction of hepatocyte senescence with moderate chronic liver injury. | Cell Death & Disease

Fig. 2: No significant induction of hepatocyte senescence with moderate chronic liver injury.

From: The extent of liver injury determines hepatocyte fate toward senescence or cancer

Fig. 2

a Detection of SA-β-gal activity in the livers of Fah−/− mice after reduction of NTBC to 2.5% for 0, 4, 8, and 12 weeks. b Staining for SAHF at 0, 4, 8, and 12 weeks. c Immunohistochemistry staining for p21 at 0, 4, 8, and 12 weeks. d Graph of the number of cells with positive for SA-β-gal, SAHF, and p21. e, f p53 and p21 expression levels in liver tissue of Fah−/− mice in chronic liver injury at 0, 4, 8, and 12 weeks. Quantitation of protein levels was on the right panel. g Expression levels of p53 and p21 in livers of Fah−/− mice under SALI or MCLI at 0, 4, and 8 weeks. Shows are mean ± S.D. **p < 0.01. *p < 0.05. Scale bar, 100 µm

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