Fig. 10: Schematic model of Sal-B in the Warburg effect and anti-carcinogenic activity. | Cell Death & Disease

Fig. 10: Schematic model of Sal-B in the Warburg effect and anti-carcinogenic activity.

From: Salvianolic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1α signaling pathway

Fig. 10

GLUT1 primarily transports glucose and HK2 catalyzes the first step of glycolysis by conversion of glucose into glucose-6-phosphate and the terminal product of glycolysis is lactate. GLUT1 and HK2 are induced by activated PI3K and HIF-1α signaling pathways. These processes can be blocked by Sal-B treatment, which was attributable to the anti-carcinogenic activity of Sal-B

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