Fig. 5: The G-CSF-mediated JAK2/STAT3 signaling pathway is, at least, partially involved in the protective effects of SIPS on mice with CTX-induced hematopoietic dysfunction. | Cell Death & Disease

Fig. 5: The G-CSF-mediated JAK2/STAT3 signaling pathway is, at least, partially involved in the protective effects of SIPS on mice with CTX-induced hematopoietic dysfunction.

From: Sarcodon imbricatus polysaccharides improve mouse hematopoietic function after cyclophosphamide-induced damage via G-CSF mediated JAK2/STAT3 pathway

Fig. 5

(a) SIPS (25, 50, and 100 mg/kg) enhanced the levels of G-CSF, G-CSFR, M-CSF, P-JAK2, P-STAT3, and c-Myc in the spleen of CTX-injected mice. The quantitative data of the b G-CSF, c G-CSFR, d M-CSF, e c-Myc, f P-JAK2, and g P-STAT3 levels were normalized by the corresponding GAPDH and related total protein expressions. Values are the percentage of the corresponding relative intensity of the control. The data are shown as the mean ± S.D. (n = 10). ##P < 0.01 and ###P < 0.001 vs. control group, *P < 0.05, ** P < 0.01 and *** P < 0.001 vs. model group

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