Fig. 8: Schematic illustration of proposed mechanisms. | Cell Death & Disease

Fig. 8: Schematic illustration of proposed mechanisms.

From: The proton pump inhibitor pantoprazole disrupts protein degradation systems and sensitizes cancer cells to death under various stresses

Fig. 8

PPI inhibited proteasome function, and induced SQSTM1 elevated autophagy as a compensatory response for impaired proteasomal degradation. PPI promotes autophagic flux in neutral pH condition while blocks autophagic flux in low pH condition. When cancer cells were under proteins overload stress caused by proteasome inhibitors and autophagic flux blockers, or mitochondrial stress caused by Bcl-2 inhibitors, the cytotoxicity of PPI would be significantly increased

Back to article page