Fig. 6: The effect of HMGA1 on tumor growth in vivo. | Cell Death & Disease

Fig. 6: The effect of HMGA1 on tumor growth in vivo.

From: HMGA1 exacerbates tumor growth through regulating the cell cycle and accelerates migration/invasion via targeting miR-221/222 in cervical cancer

Fig. 6

For the in vivo analyses, 5 × 106 Siha-HMGA1 cells and 2 × 106 MS751-shHMGA1 cells were injected subcutaneously into the posterior hip of nude mice. The mice were continuously observed for 30 days. a Images of the tumors generated by Siha-HMGA1 cells (n = 5) and MS751-shHMGA1 cells (n = 6). b Tumor volume was monitored over time using caliper measurements, the tumor volume was calculated as follows: Volume = (length × width2)/2. c Representative immunohistochemical images showing the protein expression level of HMGA1, cyclin D1, cyclin E1, MMP2, and MMP9 in the tumors from nude mice injected with Siha-CMV cells or Siha-HMGA1 cells, as well as MS751-shcon cells or MS751-shHMGA1 cells (×400). The right bars show the mean density scores of the above proteins immunohistochemistry staining by using Image Pro-Plus (IPP). *p < 0.05, **p < 0.01, and ***p < 0.001

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