Fig. 7: The schematic model of HMGA1 involved in tumor growth and metastasis of cervical cancer. | Cell Death & Disease

Fig. 7: The schematic model of HMGA1 involved in tumor growth and metastasis of cervical cancer.

From: HMGA1 exacerbates tumor growth through regulating the cell cycle and accelerates migration/invasion via targeting miR-221/222 in cervical cancer

Fig. 7

First, HMGA1 accelerates the transition of G1 into S phase in cervical cancer cells by regulating cyclin D1 and cyclin E1, which further promotes tumor growth. Second, HMGA1 promotes cell migration and invasion in cervical cancer by the miR-221/222-TIMP3-MMP2/MMP9 pathway not by the miR-221/222-MMP2/MMP9 pathway, which consequently induces tumor metastasis. Lastly, HMGA1 can directly regulate the transcription of MMP2 and MMP9

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