Table 1 Effects of Glaucocalyxin A on hematology indices in nude mice

From: Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nuclear translocation via regulating PI3K/Akt pathway

Hematological parameters

Control

Glaucocalyxin A

Standard

20 mg/kg

40 mg/kg

80 mg/kg

White blood cells (×103/ml)

7.11 ± 0.81

5.80 ± 0.65

6.94 ± 0.50

6.79 ± 0.98

4.5–9

Red blood cells (×106/blood cell)

8.71 ± 0.43

8.79 ± 0.43

8.96 ± 0.35

9.04 ± 0.17

7.51–9.66

Hemoglobin (g/dl)

14.42 ± 0.59

14.02 ± 0.60

14.08 ± 0.43

13.87 ± 0.30

12.8–16.1

Hematocrit (%)

43.02 ± 2.41

43.83 ± 3.24

44.63 ± 2.40

44.25 ± 0.71

34–50

Mean corpuscular volume (fl)

44.98 ± 1.04

46.40 ± 3.38

45.77 ± 2.82

44.90 ± 1.40

41–60

Mean corpuscular hemoglobin (pg)

14.43 ± 0.27

14.98 ± 0.36

14.60 ± 0.43

14.92 ± 0.39

13–19

Lymphocytes (%)

56.78 ± 2.38

62.00 ± 3.43

56.00 ± 1.97

69.85 ± 6.04

49–82

Monocytes (%)

3.58 ± 0.32

3.13 ± 0.83

2.52 ± 0.32

4.12 ± 0.54

2–8

Eosinophils (%)

2.17 ± 0.43

2.03 ± 0.26

2.57 ± 0.25

2.30 ± 0.30

0–3

Basophils (%)

0.52 ± 0.18

0.57 ± 0.15

0.62 ± 0.29

0.55 ± 0.13

0–3

Platelet

618.17 ± 138.49

673.67 ± 62.80

381.33 ± 52.70

259.50 ± 48.83

115–1037

  1. Each data point represents the mean ± SD of six mice.
  2. P < 0.05 versus basal levels of the control group.