Fig. 6: CPT inhibitor perhexiline reduces HCC incidence in MYC-ON mice fed with MCD diet. | Cell Death & Disease

Fig. 6: CPT inhibitor perhexiline reduces HCC incidence in MYC-ON mice fed with MCD diet.

From: Carnitine palmitoyltransferase gene upregulation by linoleic acid induces CD4+ T cell apoptosis promoting HCC development

Fig. 6: CPT inhibitor perhexiline reduces HCC incidence in MYC-ON mice fed with MCD diet.The alt text for this image may have been generated using AI.

MYC-ON mice were fed with MCD diet and injected with perhexiline or DMSO control three times per week for 5 weeks. The schematic timeline is shown in a. Liver tissue was fixed for H&E staining and the microscopic tumor number was counted. Mice were randomized to each group after doxycycline removed from drinking water (MYC-ON). Representative images of H&E staining (b) and microscopic tumor counts (c) of fixed liver tissue were shown here. d In vivo effect of perhexiline treatment on CD4+ T lymphocytes cell apoptosis. *P < 0.05

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