Fig. 7: Schematic picture showing CPT genes are upregulated through PPAR-α by C18:2. | Cell Death & Disease

Fig. 7: Schematic picture showing CPT genes are upregulated through PPAR-α by C18:2.

From: Carnitine palmitoyltransferase gene upregulation by linoleic acid induces CD4+ T cell apoptosis promoting HCC development

Fig. 7: Schematic picture showing CPT genes are upregulated through PPAR-α by C18:2.The alt text for this image may have been generated using AI.

C18:2 activates the lipid receptor and transcription activator PPAR-α, which translocated to nucleus and upregulates the expression of CPT genes (CPT1 and CPT2). Therefore, increased level of CPT enzymes on mitochondrial membrane promotes the mitochondrial uptake of C18:2, resulting in elevated ROS and cell apoptosis

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