Fig. 4: Hedgehog signaling was aberrantly activated in myofibroblast differentiation of lung-resident mesenchymal stem cells (LR-MSCs) and fibrotic lung tissues. | Cell Death & Disease

Fig. 4: Hedgehog signaling was aberrantly activated in myofibroblast differentiation of lung-resident mesenchymal stem cells (LR-MSCs) and fibrotic lung tissues.

From: The hedgehog and Wnt/β-catenin system machinery mediate myofibroblast differentiation of LR-MSCs in pulmonary fibrogenesis

Fig. 4

a, b The expressions of Gli1, Gli2 and Gli3 in TGF-β1-treated LR-MSCs (a) and bleomycine (BLM)-induced mouse fibrotic lung tissues (b) were analyzed by quantitative PCR. * P < 0.05 vs. Con or Saline, ** P < 0.01 vs. Con or Saline. c–f The level of Gli1 in TGF-β1-treated LR-MSCs (c, e) and bleomycine (BLM)-induced mouse fibrotic lung tissues (d, f) was determined by western blot (c, d) and immunofluorescence staining (e, f)

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