Fig. 7: Inhibition of PI3K/Akt and MAP kinases ERK-1/2 but not JNK attenuates Fas-L-induced proliferation. | Cell Death & Disease

Fig. 7: Inhibition of PI3K/Akt and MAP kinases ERK-1/2 but not JNK attenuates Fas-L-induced proliferation.

From: Fas-L promotes the stem cell potency of adipose-derived mesenchymal cells

Fig. 7

Cultured ASCs (P2-4) were treated with the indicated combination of mega-Fas-L, Z-VAD-fmk, LY294002 (PI3K inhibitor), AZD6244 (ERK-1/2 inhibitor), and SP600125 (JNK inhibitor). Four days later, cells were removed from plates by trypsin and cells were counted using a standard cell counter. Passage 2–4 ASCs were used in all experiments. The experiment was repeated three times using cells from three independent patients. Data are presented as the mean ± standard deviation

Back to article page