Fig. 4: ARHGAP15 modulated PTEN/AKT/FOXO1-signaling pathway.

a, b The protein levels of several pivotal molecules in HT29 (a) and RKO (b) cells after transfected with pLVX-ARHGAP15 or pLVS-NC. c The protein levels of several pivotal molecules in LoVo cells after transfected with ARHGAP15 shRNA (sh-ARHGAP15) or control shRNA (sh-NC). Experiments were repeated three times independently. NS: no significant difference; ** P < 0.01; *** P < 0.001