Fig. 7: ARHGAP15 hyperexpression suppressed the formation and distant metastasis of CRC in vivo. | Cell Death & Disease

Fig. 7: ARHGAP15 hyperexpression suppressed the formation and distant metastasis of CRC in vivo.

From: Decreased expression of ARHGAP15 promotes the development of colorectal cancer through PTEN/AKT/FOXO1 axis

Fig. 7

CRC xenograft mouse model was established to validate the antitumor effect of ARHGAP15 overexpression in vivo. Two groups were divided according to the subcutaneously injection of pLVX-NC or pLVX-ARHGAP15 transfected RKO cells to nude mice (six mice per group). a The pictures of the tumor-bearing mice and tumors. b Tumor growth curves of the two groups. c Western blot analysis of the crucial molecules in the tumors. d HE staining of lung metastases. Scale bar: 100 μm. NS: no significant difference; *P < 0.05; **P < 0.01; *** P < 0.001

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