Fig. 3: Autocrine CTRP9 of cardiomyocyte origin protects against SI/R-induced apoptosis. | Cell Death & Disease

Fig. 3: Autocrine CTRP9 of cardiomyocyte origin protects against SI/R-induced apoptosis.

From: Cardiac-derived CTRP9 protects against myocardial ischemia/reperfusion injury via calreticulin-dependent inhibition of apoptosis

Fig. 3: Autocrine CTRP9 of cardiomyocyte origin protects against SI/R-induced apoptosis.

a, b CTRP9 expression in NCMs after hypoxia for 12 h followed by reoxygenation for 3 and 6 h. c–e Cardiomyocytes were infected with negative control (NC) or CTRP9 lentivirus (LV. CTRP9) and treated with CTRP9 antibody (Ab) or control IgG. Cell apoptosis were determined by LDH release and caspase-3 activity. f, g Western blot analysis of Bcl-2 and Bax expression. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01 vs. control group; #P < 0.05 vs. Reoxygen 3 h group; $$P < 0.01 between the two groups connected by line. N = 3–6

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