Fig. 8: Proposed mechanism responsible for autocrine CTRP9 of cardiomyocyte origin against MI/R injury. | Cell Death & Disease

Fig. 8: Proposed mechanism responsible for autocrine CTRP9 of cardiomyocyte origin against MI/R injury.

From: Cardiac-derived CTRP9 protects against myocardial ischemia/reperfusion injury via calreticulin-dependent inhibition of apoptosis

Fig. 8

Briefly, CTRP9 binds to ER molecular chaperone CRT in the cytoplasm of cardiomyocyte under physiological conditions. When subjected to MI/R injury, CRT translocates to cell surface and associates with autocrine CTRP9. CTRP9–CRT complex activates PKA-CREB pro-survival signaling and inhibits ER stress-related apoptotic signaling, directly protecting against MI/R injury

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