Fig. 2: GL22 triggers mitochondrial dysfunction in Huh7.5 cells. | Cell Death & Disease

Fig. 2: GL22 triggers mitochondrial dysfunction in Huh7.5 cells.

From: The natural compound GL22, isolated from Ganoderma mushrooms, suppresses tumor growth by altering lipid metabolism and triggering cell death

Fig. 2: GL22 triggers mitochondrial dysfunction in Huh7.5 cells.

a GL22 caused primary changes of mitochondrial morphology in Huh7.5 cells. Huh7.5 cells treated with 25 μM GL22 for 0, 12, and 24 h were harvested, stained, and photographed by transmission electron microscopy. Right panels are high-power images for left panels. MT mitochondria, LD lipid drops. b Effects of GL22 on Huh7.5 proliferation with or without glucose (36 h). c–e GL22 treatment of Huh7.5 cells inhibited ATP production, inhibited O2 respiration rate and increased lactate production. Values represent the means ± SD of triplicate measurements. *P < 0.05, **P < 0.01 vs. control

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