Fig. 5: GL22 inhibits the expression of FABPs. | Cell Death & Disease

Fig. 5: GL22 inhibits the expression of FABPs.

From: The natural compound GL22, isolated from Ganoderma mushrooms, suppresses tumor growth by altering lipid metabolism and triggering cell death

Fig. 5

a The expression of FABPs (FABP1, 4, 5) decreased in Huh7.5 cells treated with GL22 for 24 h. b GL22 inhibited the expression of FABPs (FABP1/4/5) in xenografts. Xenograft animals were administrated GL22 at dose of 50 mg/kg, whereas control animals received equivalent volumes of solvent. GL22 treatment was initiated when tumors were palpable and continued for 1 week. c–e BMS309403 treatment caused LD accumulation, cardiolipin content reduction and cell viability disease in Huh7.5 cells after cells were pre-treated for 10 min with 50 μM BMS309403, which partically phenocopy the effect of GL22. After treatment, LD and cardiolipin content were measured using flow cytometry as described in Fig. 3. Data of three independent experiments are shown. *P < 0.05, **P < 0.01 vs. control

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