Table 1 SNVs and InDels of critical genes in penile cancer cell lines
Genes | Penl1 | Penl2 | 149RCa | 149RM | LM156 |
|---|---|---|---|---|---|
Tumor suppressor | |||||
TP53 | R244P*, P33R | R234H | R209Q*, R71C*, P33R | R209Q*, R71C*, P33R | P33R |
PTCH1 | T1195S | T1195S | P1315L | P1315L | P1315L |
ERCC5 | G1053R$ | G1053$ | R214C$, G1053R$ | R214C$, G1053R$ | G1053R$ |
CDKN2A | R80X* | R80X* | H83Y* | H83Y* | – |
FANCD2 | N791S$, Splicing | Splicing | Splicing | Splicing | – |
TET2 | – | – | I1762V | I1762V | – |
ATM | – | R2691C* | – | – | – |
BRCA1 | S1566G | ||||
FBXW7 | – | – | S25X | – | – |
MSH6 | – | R922Q | – | – | – |
Oncogenes | |||||
CLTCL1 | V1201fs$ | E458Q$, V1201fs$ | V1201fs$ | V1201fs$ | V1201fs$ |
USP6 | I67M$, R68W$, R69W$ | I67M$, R68W$, R69W$, M80I$ | I67M$, R68W$, R69W$ | I67M$, R68W$, R69W$ | I67M$, R68W$, R69W$ |
NOTCH2 | N46S* | P6fs | N46S, S220R, P227H, T235S | N46SΔ | N46S |
NOTCH1 | G427D$ | C467F$ | – | – | D1200N*$ |
HRAS | – | – | G13V* | G13V* | G13R* |
KDR | Q472H | Q472H | Q472H | ||
CIITA | I729M$ | Q21H$ | Q21H$ | ||
NIN | E1099K$ | C1036F | |||
ERBB2 | Q902X*$ | – | – | – | R143Q* |
AFF3 | H914Q$ | H914Q$ | |||
NACA | K416R$ | K416R$ | |||
PCSK7 | V143F$ | T743N$ | |||
AFF3 | H914Q$ | – | – | – | H914Q$ |
BCL11A | – | R249T | – | E539K | – |
ROS1 | – | P224S*$ | – | – | – |
ALK | R291H* | – | – | – | – |
ABL1 | – | – | – | – | K404T*$ |
JAK3 | – | – | – | – | I688F$ |
Protein kinases | |||||
ADCK5 | L419fs | L419fs | L419fs | L419fs | L419fs, D423fs$ |
MAP2K3 | P40T$ | P40T$ | P40T$ | P40T$ | P40T$ |
CDK11A/B | R117delinsKER | R117delinsKER | R117delinsKER | R117delinsKER | R117delinsKER |
MAP3K4 | p.1186_1186del | p.1186_1186del | p.1186_1186del | p.1186_1186del | p.1186_1186del |
WNK1 | V724fs$ | P1989A$ | V724fs$, R1076Q$ | V724fs$, R1076Q$ | |
FPGT-TNNI3K | P830T$ | M931V$ | – | M931V$ | T751M$ |
LIMK2 | Q684R | Q684R | Q684R | Q684R | |
TTN | T1968A$, R8985C$, P18296A$, R24838H$ | E8785Q$ | V5249F$, M11124T$ | V5249F$, M11124T$ | – |
WNK2 | V828M | V828M | – | – | A690P$, V828M, S1789fs$ |
TGFBR2 | – | R522X | S320X | S320X | – |
TNK2 | – | R162W | – | – | R162W |
Transcription factors | |||||
BCLAF1 | G64A$, T837N$ | G64A$, R697H$, S716R$, T837N$ | G64A$, G208V$, T837N$, R864C$ | G64A$, T837N$ | G64A$, R697H$, S716R$, T837N$, R864C$ |
ZBTB33 | S188delinsSD | S188delinsSD | S188delinsSD | S188delinsSD | S188delinsSD |
MAML3 | Q498fs$, Q502fs$, p.768_768del | Q498fs$, Q502fs$, p.768_768del | Q498fs$, Q502fs$, Q505fs, p.768_768del | Q498fs$, Q502fs$, p.768_768del | Q505fs, p.768_768del |
FOXE1 | p.169_170del | p.169_170del | p.169_170del | p.169_170del | p.169_170del |
DCP1A | Splicing$ | Splicing$ | Splicing$ | Splicing$ | Splicing$ |
CREB3L1 | Splicing$ | Splicing$ | Splicing$ | Splicing$ | Splicing$ |
TBP | p.52_52del | p.52_52del | p.52_52del, p.56_56del$ | p.52_52del, p.56_56del$ | – |
PRDM2 | T501delinsTP | T501delinsTP | – | T501delinsTP | C133Y$, T501delinsTP |
ZNF83 | p.267_295del | p.267_295del | – | p.267_295del | – |
SMARCA2 | – | p.223_223del | p.223_223del | – | p.223_223del |
CASZ1 | P1738R$ | G1732S$ | – | R277W | – |
NCOA3 | – | – | p.1247_1249del | p.1247_1249del | p.1254_1254del |
MEF2A | p.342_342del | – | p.342_343del | p.342_343del | – |
HOXD9 | P265delinsPQ | – | – | – | P265delinsPQ |
IRF5 | p.168_177del | p.168_177del | – | – | – |
ZNF169 | R382C | P72L | – | – | – |
PRDM10 | – | D180V$ | – | – | L930V$ |
NR1D2 | – | Q232H$ | – | – | F96Y$ |
FAM20C | L317_D318delinsLDRX$ | L317_D318delinsLDRX$ | – | – | – |
EP300 | – | – | S507G | S507G | – |
STAT2 | – | – | F90S$ | F90S$ | – |
Other important genes | |||||
CD207 | Splicing$ | Splicing$ | Splicing$ | Splicing$ | Splicing$ |
SIRPA | D95fs$ | D95fs$ | D95fs$ | D95fs$ | D95fs$ |
LILRB3 | V341M$ | – | V341M$ | V341M$ | V341M$ |
PDE4DIP | Q1665fs$ | L764fs$ | – | – | L764fs$ |
CD33 | N237fs$ | – | N237fs$ | N237fs$ | – |
SELPLG | p.151_161del | – | p.151_161del | p.151_161del | – |
