Fig. 5: Effects of URB on the AKT/mTOR and AMPK/mTOR signaling after CCH. | Cell Death & Disease

Fig. 5: Effects of URB on the AKT/mTOR and AMPK/mTOR signaling after CCH.

From: Inhibition of excessive autophagy and mitophagy mediates neuroprotective effects of URB597 against chronic cerebral hypoperfusion

Fig. 5: Effects of URB on the AKT/mTOR and AMPK/mTOR signaling after CCH.The alternative text for this image may have been generated using AI.

a, b Representative western blot for p-AKT, AKT, p-AMPK, AMPK, p-mTOR, mTOR, and β-actin in frontal cortex and hippocampus, respectively. c, d Relative densitometric density analysis of the p-AKT protein bands (p-AKT/AKT) in frontal cortex and hippocampus, respectively. e, f Relative densitometric density analysis of the p-AMPK protein bands (p-AMPK/AMPK) in frontal cortex and hippocampus, respectively. g, h Relative densitometric density analysis of the p-mTOR protein bands (p-mTOR/mTOR) in frontal cortex and hippocampus, respectively. Data are expressed as mean ± SEM (n = 5). *P < 0.05 versus sham group. **P < 0.05 versus BCCAo group

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