Fig. 5: Targeted deletion of Smo in livers inhibits hepatocyte proliferation and EMT after PH. | Cell Death & Disease

Fig. 5: Targeted deletion of Smo in livers inhibits hepatocyte proliferation and EMT after PH.

From: MicroRNA-378 is involved in hedgehog-driven epithelial-to-mesenchymal transition in hepatocytes of regenerating liver

Fig. 5

a Images, H & E-, and Ki67-stained sections of livers from AAV8-TBG-GFP or AAV8-TBG-Cre-treated mice at 48 h after PH (N = 4 per group). Representative images of PH liver at 48 h were shown (liver image: scale bar = 50 mm/H&E and Ki67 stain: scale bar = 50 µm). b Quantitative Ki67-stained data from these mice. Ki67-positive hepatocytic cells were quantified by counting the total number of Ki67-positive cells per field. Mean ± s.e.m. results are graphed (one-way ANOVA with Tukey corrections, *p < 0.05 **p < 0.005) (c) qRT-PCR for Smo, miR-378, Gli3, p65, Tgfb, Snail, Vimentin and E-cadherin in these livers. All results of relative expression values are shown as mean ± s.e.m. of triplicate experiments (one-way ANOVA with Tukey corrections, *p < 0.05 **p < 0.005)

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