Fig. 7: CDKN1A is a bona target of SNHG1, and CDKN1A overexpression suppresses CCA cell proliferation and metastasis. | Cell Death & Disease

Fig. 7: CDKN1A is a bona target of SNHG1, and CDKN1A overexpression suppresses CCA cell proliferation and metastasis.

From: Epigenetic silencing of tumor suppressor gene CDKN1A by oncogenic long non-coding RNA SNHG1 in cholangiocarcinoma

Fig. 7

a Expression level of CDKN1A in cholangiocarcinoma by analysis of GES76297 data. b CDKN1A was detected in 17 pairs of CCA tissues by qRT-PCR. c–f HuCCT1 and RBE cells transfected with vector/pcDNA-CDKN1A/pcDNA-SNHG1 and with SNHG1 followed by transfection with CDKN1A. After transfection, cells were analyzed by CCK8 assays (c, d) and Transwell assays (e, f). g Proposed model of SNHG1 regulating CDKN1A expression to promote CCA tumor growth. Error bars indicate means ± SD. *P < 0.05; **P < 0.01; n.s. not significant.

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