Fig. 5: Nintedanib reduced skeletal muscle fibrosis in mdx mice. | Cell Death & Disease

Fig. 5: Nintedanib reduced skeletal muscle fibrosis in mdx mice.

From: Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy

Fig. 5

Representative pictures of immunofluorescence staining for collagen VI in quadriceps (a–c), diaphragm (d–f), and tibialis anterior (g–i) of WT, mdx, and nintedanib-treated mdx mice. Endomysial collagen deposition increased in all mdx muscles compared with WT group and decreased in nintedanib-treated mdx muscles, significantly in quadriceps (j) and diaphragm (k) but not in tibialis anterior (l) compared with non-treated mdx mice. Data are expressed as means ± SD. Genetic background mouse strain C57BL (WT); n = 5, mdx mice (mdx), n = 5; nintedanib-treated mdx mice (mdx + Ninte), n = 7. *P < 0.05. Scale bar of quadriceps and tibialis anterior = 200 µm. Scale bar of diaphragm = 100 µm.

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