Fig. 7: Nintedanib decreased collagen I expression in mdx muscles. | Cell Death & Disease

Fig. 7: Nintedanib decreased collagen I expression in mdx muscles.

From: Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy

Fig. 7

Western blotting of Collagen I in quadriceps (a), diaphragm (b), and tibialis anterior (c) showed a reduction in the protein expression in diaphragm (e) and tibialis anterior (f) but not in quadriceps (d) of nintedanib-treated mdx mice compared with mdx mice by quantification of Collagen I normalized to α-tubulin levels. Data are expressed as means ± SD. Genetic background mouse strain C57BL (WT); n = 4, mdx mice (mdx), n = 4; nintedanib-treated mdx mice (mdx + Ninte), n = 4. *P ≤ 0.05 and **P ≤ 0.01

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